Pulmonext 5 Tablet

Description

Pulmonext 5 Tablet

Overview

Pulmonext 5 contains ambrisentan, a specialist medicine for pulmonary arterial hypertension (PAH). It helps reduce resistance in the pulmonary arteries and may improve exercise ability and delay worsening. It is sometimes used with tadalafil. Treatment requires specialist oversight, pregnancy prevention and clinical monitoring.

What it is used for

Treatment of pulmonary arterial hypertension in appropriately assessed patients, alone or in combination according to specialist guidance. It is not a general treatment for ordinary systemic hypertension.

How it works

Endothelin-1 causes blood-vessel constriction and cell proliferation. Ambrisentan selectively blocks endothelin-A receptors, helping pulmonary arteries relax and reducing pressure load on the right side of the heart.

How to take it

Take exactly as prescribed, with or without food, at a consistent time. Swallow tablets whole; do not split, crush or chew unless the specific product information explicitly permits it. Do not stop independently. Attend all pregnancy tests, blood counts and clinical reviews.

Common side effects

Peripheral oedema, nasal congestion, sinus symptoms, flushing, headache, palpitations, dizziness, tiredness, nausea and reduced haemoglobin may occur. Fluid retention may be more frequent in combination therapy.

When to seek urgent medical help

Contact the specialist urgently for rapid weight gain, worsening swelling or breathlessness, fainting, marked weakness, jaundice, dark urine, persistent nausea, facial or throat swelling or other signs of severe allergy.

Warnings and precautions

Ambrisentan can cause embryo-fetal harm and is contraindicated in pregnancy. Reliable contraception and scheduled pregnancy testing are required for patients who can become pregnant. Tell the specialist about liver disease, anaemia, fluid retention, heart failure, idiopathic pulmonary fibrosis, pregnancy plans or breastfeeding.

Interactions

Cyclosporine can substantially increase ambrisentan exposure and may require dose limitation. The specialist should review all PAH medicines, blood-pressure medicines and other prescription, non-prescription or herbal products.

Missed dose

Follow the patient leaflet or prescriber's instructions. If it is almost time for the next scheduled dose, do not take a double dose to compensate. Ask a pharmacist or prescriber if unsure.

Storage

Keep in the original tightly closed container or blister at room temperature and away from excess moisture. Store out of children's reach and follow the actual pack label.

Important catalogue notice

This information summarises the supplied product document and reviewed prescribing information. It is not a diagnosis, prescription or substitute for the leaflet supplied with the medicine. Formulation, excipients, pack size, manufacturer, storage limits and authorised indications can differ by market and batch; verify the physical pack and consult a qualified healthcare professional before use.