Bosentas 62.5 Tablet

Description

Bosentas 62.5 Tablet

Overview

Bosentas 62.5 contains bosentan, a specialist prescription medicine for pulmonary arterial hypertension (PAH). PAH is high pressure in the arteries carrying blood from the heart to the lungs. Treatment may improve exercise ability and delay clinical worsening in appropriately selected patients, but it requires specialist supervision and regular laboratory monitoring.

What it is used for

Treatment of pulmonary arterial hypertension in eligible patients. The exact indication, starting strength and later dose are determined by a PAH specialist according to age, body weight, liver function, symptoms and other medicines.

How it works

Endothelin-1 is a naturally occurring substance that strongly narrows blood vessels. Bosentan blocks endothelin A and B receptors, helping pulmonary blood vessels relax and reducing resistance against which the right side of the heart pumps.

How to take it

Take only according to the specialist's schedule, with or without food and at consistent times. Do not start, stop or change the dose independently. Required blood tests and pregnancy testing must be kept up to date throughout treatment.

Common side effects

Headache, flushing, nasal congestion, dizziness, ankle or leg swelling, palpitations, tiredness and reduced haemoglobin may occur.

When to seek urgent medical help

Contact the specialist urgently for yellow skin or eyes, dark urine, persistent nausea or vomiting, unusual tiredness, right-upper abdominal pain, fainting, worsening breathlessness, rapid weight gain, marked swelling or signs of an allergic reaction.

Warnings and precautions

Bosentan can cause serious liver injury and embryo-fetal harm. Liver enzymes require regular monitoring and haemoglobin is checked periodically. It is contraindicated in pregnancy; patients who can become pregnant need reliable contraception and scheduled pregnancy tests. Hormonal contraception alone may be less reliable.

Interactions

Bosentan has major interactions. Cyclosporine and glyburide/glibenclamide are notable examples that may be contraindicated or avoided. It can interact with warfarin, sildenafil, rifampicin, azole antifungals, HIV medicines and hormonal contraceptives. Specialist medication review is essential.

Missed dose

Follow the patient leaflet or prescriber's instructions. If it is almost time for the next scheduled dose, do not take a double dose to compensate. Ask a pharmacist or prescriber if unsure.

Storage

Store in the original pack at room temperature, away from excess heat and moisture and inaccessible to children. Follow the actual pack label and local dispensing instructions.

Important catalogue notice

This information summarises the supplied product document and reviewed prescribing information. It is not a diagnosis, prescription or substitute for the leaflet supplied with the medicine. Formulation, excipients, pack size, manufacturer, storage limits and authorised indications can differ by market and batch; verify the physical pack and consult a qualified healthcare professional before use.